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Molecular biology of glutathione peroxidase 4: from genomic structure to developmental expression and neural function

This may explain why the brain is particularly susceptible to aggregation-related neurodegenerative diseases

By slowing down the activity of tyrosinase, Glutathione effectively reduces the formation of excess melanin, particularly the darker type known as eumelanin, and encourages the production of lighter pheomelanin

Upon binding of a ligand to a death receptor, Fas-associated death domain protein (FADD) is recruited and the death-inducing signaling complex (DISC) (for FasL/FasR, TRAIL/TRAIL-R1 or TRAIL-R2) or complex II (in the case of TNF/TNF-R1) is formed