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61.7 12.4 years, p = 0.011)

Finally, although the total brain lipid content may decrease with age, the enzymes responsible for incorporating PUFAs into membrane phospholipids remain active, ensuring the continued presence of the necessary substrates for the final execution step of ferroptosis (75)

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In this alternate pathway, phosphatidylethanolamine methyltransferase catalyzes a series of reactions by which three methyl groups derived from SAM are donated to phosphatidylethanolamine ( Figure 1 )