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Plateau Breaking Strategies Researchers who observe diminishing returns after extended use may employ several strategies: Brief Dose Increase : Temporarily increasing dose by 25-30% for 1-2 weeks may overcome adaptation, followed by return to standard dosing

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A drug example is thiopental, a short-acting barbiturate sedative hypnotic for which high blood flow to the brain initially delivers sufficient thiopental to the brain to cause anesthesia