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In that study, people randomly assigned metformin lost an average of 2% of their body weight

Theoretically, if homocysteine concentrations become extremely low, substrate availability for glutathione synthesis could also be reduced

The majority of SAHHs/SIHHs analysed in this work containing a shortened C-terminus are (hyper-)thermophilic, confirming the assumption 36 that the length of the C-terminus correlates with the thermophilicity of the enzymes 46