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Zinc and iron supplementation can be worthwhile if a deficiency is present

191 In addition, O3,4,5-tri-caffeoylquinic acid enhances pigmentation by activating -catenin in follicular melanocytes and upregulating the expression of MITF, a target gene, in caffeoylquinic acid

The field is still trying to parse out which epigenetic changes are associated with MS and what causes them

The resolution of this basic issue will depend on future clinical interventions that target these pathways to ascertain their role in cognitive dysfunction and neuropathogenesis