2-[4-(carboxymethyl)piperazin-1-yl]acetic acid dihydrochloride fluorescein NCCOCCOCCOCCOCCOCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95%

NCCOCCOCCOCCOCCOCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

8 SMILES ClCCOCC(=O)NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

96 SMILES Cl

GW5074 reduces mHTT levels through autophagic degradation by interacting with both the autophagosome protein microtubule-associated protein 1A/1B light chain 3 (LC3)1 and mutant huntingtin protein (mHTT)

2-[4-(carboxymethyl)piperazin-1-yl]acetic acid dihydrochloride fluorescein NCCOCCOCCOCCOCCOCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95%Nitrogen Heterocycle Based Linker (NHBL). Binfunctional carboxylic acid carboxylic acid linker. Product Name 2 [4 (carboxymethyl)piperazin 1 yl]acetic acid dihydrochloride Synonyms CAS Number 127178 07 8 Related CAS 5430 78 4 Molecular Formula C8H16Cl2N2O4 Molecular Weight 275. 13 SMILES Cl. Cl. OC(=O)CN1CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of