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The receptors on the dopaminergic neurons bind to this tobacco component to open the channel to enable the conductance of cations like potassium, calcium, and sodium

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Consequently, the necessity for animal testing of tobacco products should be questioned, in line with a general shift of focus in modern toxicology ( Figure 2 In Europe, toxicological assessments of tobacco products are aimed to exclude elevated risks in relation to conventional products, but not to confirm less hazardous product properties