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TGF- directly elevates transcription of collagen genes (COL1A1, COL3A1) via the Smad pathway and induces additional pro-fibrotic mediators (CTGF, PDGF, FGF), synergistically promoting fibroblast proliferation and collagen synthesis ( EMT not only directly damages alveolar architecture but its heterogeneity is closely associated with clinical differences among disease subtypes

Gasca-Salas C, Clavero P, Garca-Garca D, Obeso JA, Rodrguez-Oroz MC

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10.1016/j.celrep.2014.12.036 [DOI] [PMC free article] [PubMed] [Google Scholar] Wick G., Schett G., Amberger A., Kleindienst R., Xu Q