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Conversely, adipocytes from obese mice express twofold lower levels of Gs, a subunit of the GTP-binding protein through which beta-adrenergic receptors stimulate adenylyl cyclase (38)

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In fact, according to the Centers for Disease Control and Prevention (CDC), about 40.3% of American adults were obese in 2021-2023, highlighting the widespread need for effective weight management strategies

Acetatifactor relative abundance was greater in 5A-1MQ-treated mice switched from WD to LD compared to WD (without FDR correction) and LD controls (Supplementary Fig