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Then an aliquot of the obtained cDNA was subjected to 40 cycles of Real-time PCR amplification (95C, 10 sec

Gene therapies targeting ECM components or the signaling pathways involved in TM cell contractility could restore normal outflow dynamics

High doses of B12, often used to treat deficiencies, may cause side effects such as headaches, nausea, diarrhea, fatigue or weakness, and tingling in the hands and feet

Recent analyses highlight that tofersen not only validates the genetic approach but also enhances therapeutic opportunities by potentially altering the disease course when initiated early, though accessibility and long-term management strategies remain areas for development (46)