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An intense antiinflammatory response along with immune dysregulation and exhaustion are associated with immune cell paralysis (44)

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Future research should investigate the synergistic impact of different RCD modalities on AML stem cell maintenance, chemoresistance and microenvironmental remodeling in order to enable the development of personalized therapies that precisely target death pathways

In addition to liver-derived serum IGF-1 (endocrine), there is strong evidence that locally expressed IGF-1 (autocrine/paracrine) regulates longitudinal bone growth in the growth plate [87,127132]