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doi: 10.1038/s41467-021-27197-5 44 SzymanskaBWilczynska-KalakUKangMHLiemNLCarolHBoehmIet al

Its k cat / K m values toward tyrosine and DOPA are 600 and 181 s 1 mM 1 , respectively, which are 2.78- and 1.79-fold higher than the WT enzyme

In SURPASS-2, a head-to-head diabetes trial, Tirzepatide 15 mg outperformed Semaglutide 1 mg, producing 11.2 kg weight loss versus 5.7 kg (Frias et al., NEJM 2021

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