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Currently, activating key innate immune pathwaysparticularly the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathwayhas emerged as a promising strategy to enhance antitumor immune responses [8,9,10,11,12,13,14,15,16,17]

Alpha-1 antitrypsin deficiency affects approximately 1 in 2,0006,000 individuals globally, with an estimated 3.4 million people harboring severe deficiency alleles and over 116 million carriers worldwide [20, 21]

Petroff D, Blank V, Newsome PN, ShalimarVoican CS, Thiele M, deLedinghen V, Baumeler S, Chan WK, Perlemuter G, Cardoso AC, Aggarwal S, Sasso M, Eddowes PJ, Allison M, Tsochatzis E, Anstee QM, Sheridan D, Cobbold JF, Naveau S, Lupsor-Platon M, Mueller S, Krag A, Irles-Depe M, Semela D, Wong G, Wong VW, Villela-Nogueira CA, Garg H, Chazouilleres O, Wiegand J, Karlas T