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Patients with Renal or Hepatic Impairment Ceftriaxone is excreted via both biliary and renal excretion (see CLINICAL PHARMACOLOGY)

When accounting for the influence of body weight, no additional differences in pharmacokinetics were found between children and adults

Furthermore, most previously developed nanotherapies were formulated by loading anti-coagulants and/or thrombolytic agents into different NPs, which cannot alleviate other pathological changes closely related to thrombosis, such as endothelial injury and systemic/local inflammation and oxidative stress, thereby resulting in recurrent symptoms after temporary remission of thrombosis and the occurrence and development of other cardiovascular diseases 68

The statistical approach ensured rigorous evaluation of data, minimizing biases, and enhancing the reliability of findings