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Copper revealed its cytotoxic activity by enhancing endoplasmic reticulum stress and disrupting calcium ions Ca 2+ homeostasis [85]

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For example, transcription factors play an important role in regulating transcription by binding to specific recognition sites on the chromosome, often at a genes promoter, and interacting with other proteins in the nucleus

Age-related changes have been described in OLGs, notably the decrease in myelinating capacity with increased age [87], but it has also been suggested that there is a loss of epigenetic memory in these cells [92]