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(Reference Mao, Gu, Chen, Yu and He70) Furthermore, down-regulation of other enzymes, such as matrix metalloproteinase-12 (MMP-12), extracellular signal-regulated kinase, nuclear factor-kappa B (NF-B), phosphoinositide-3 kinase (PI3K), and haem oxygenase-1 (OH-1), have been hypothesised as possible mechanisms through which green tea polyphenols might equilibrise the production of ROSs and their eradication