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As per mice studies, lactoferrin downregulates levels of TNF- and IL-6

The prevalence of biopsy-proven CD in patients with dyspepsia is 1%, similar to that of the general population 12 and therefore, systematic screening for CD is not recommended based on disease prevalence alone

NHS approach to B12 deficiency: NICE Clinical Knowledge Summaries recommend investigating B12 deficiency in patients presenting with macrocytic anaemia, unexplained neurological symptoms, or risk factors including pernicious anaemia, gastrectomy, malabsorption disorders, metformin use, proton pump inhibitors, or nitrous oxide exposure

Chloroplasts Asc is also a cofactor for violaxanthin de-epoxidase where it participates within the production of xanthophylls which are directly involved in quenching of excessive excitatory energy on PS II (Davey et al., 2000)