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The redox state of the GSH/GSSG couple can serve as an important indicator of redox environment (2931), and changes in this couple correlate with multiple cellular processes, including cell differentiation (3237), cell proliferation (3237), and cell apoptosis (3842)

Since we previously found that ser/gly rewired tumors produce and secrete high levels of pathway metabolites into the circulation, we hypothesized that metabolomic analysis of blood plasma samples from patients with NSCLC could give valuable insight into ser/gly metabolic rewiring in tumor cells in response to RT [24]

In the following sections, known and well-established drug targets are reviewed, along with other molecular changes induced by either MPH or LDX, which might be valuable information to help fully understand the molecular consequences of stimulant treatment and how these mechanisms impact clinical observations

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