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J Forensic Sci

Ropivacaine reduces cisplatin resistance in colorectal cancer by blocking the SIRT1/NRF2 pathway [101]

Immunofluorescent assay (IFA) of Ki67 and LGR5 further indicated a loss of LGR5 + ISCs in the crypt compartments of non-treated Veh controls and restored by IPA treatment at D7 when exposed to DSS, whereas no significant differences in immunostaining were seen between IPA- and Veh-treated mice at D0 (Fig