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Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced obese mice

Mitochondrial homeostasis regulation by NAD + Mitochondria are the source of high-yield energy production through Oxphos and the ETC to generate ATP, of which levels must be maintained for cellular homeostasis

In the aforementioned study from our group, adult mice with partial IGF-1 also displayed decreased expression of genes involved in lipid metabolism (ATP-citrate lyase, acetyl-CoA acyltransferase 1B, acetyl-CoA acetyltransferase 1) and cholesterol synthesis and transport (Both HMG-CoA reductase and synthase, LDL-related protein 1, proprotein convertase subtilisin/Kesin type 9), resulting in dyslipidaemia