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Assuming 0.34 nm/base pair for the helical pitch and 2 nm for the diameter of double-stranded (ds) DNA, the lengths of ADC, ADC/siRNA and ADC/siRNA/Ap-YTDB should be 17 nm, 17 nm and 42.4 nm, respectively

doi: 10.1016/j.jalz.2019.04.001 123 VerseleR.CorsiM.FusoA.SevinE.BusinaroR.GosseletF.et al

Toxicon 248, 108049

DAA, particularly neurotoxic C3 + reactive astrocytes, can be induced by factors such as IL-1, TNF-, and C1q, released from activated neuroinflammatory microglia, as mentioned (Liddelow et al., 2017)