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However, silencing HO-1 increases the growth inhibition of hepatocellular carcinoma (HCC) cells after ferroptosis triggering, suggesting that HO-1 also has an anti-ferroptosis effect (36)

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The underlying mechanisms are multifactorial and not fully understood, but increasing evidence highlights the gutbrain axis and the intestinal microbiome as critical contributors to disease onset and progression (He et al., 2023