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In patients with Addisonian Pernicious Anemia, parenteral therapy with vitamin B12 is the recommended method of treatment and will be required for the remainder of the patients life

Aunque la produccin de la S-Adenosil metionina no es B 12 dependiente, ayuda en el reciclado para la provisin de un sustrato adecuado para este (el aminocido esencial metionina), ya que es asistido por la B 12

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This neuroadaptive state can contribute to the development of tolerance, dependence, and withdrawal symptoms, further complicating the recovery process for individuals with AUDs (Bhandari et al