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when this channel becomes mislocalized, it may facilitate the spread of ROS, further exacerbating oxidative stress [436, 437]

R proteins (haptocorrins), nonspecific binding proteins of salivary and gastric origin, attach cobalamin after it is released from food in the stomach

The key safety advantage lies in immunogenicity

Although more intensive regimens, such as docetaxel plus CF (DCF), have demonstrated improved survival [3, 4], CF-based therapy continues to play a central role in EC treatment, including in combination with immune checkpoint inhibitors for advanced or recurrent disease [5,6,7]