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Acetazolamide is the first-line of prophylaxis, FDA approved drug for AMS that works at the level of kidneys and causes bicarbonate diuresis and metabolic acidosis, promoting ventilatory acclimatization to hypoxia 25

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Damage to mitochondrial DNA results in loss of mitochondrial membrane potential, impairment in the electron transport chain, and drives the immune and inflammatory responses (Liu and Chen, 2017), (Figure 3)