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References Gisondi P, Bellinato F, Targher G, Idolazzi L, Girolomoni G

Marvin-Peek J , Atluri H, Short NJ, Maiti A, Takahashi K, Loghavi S, Lachowiez CA, Valero YA, Montalban-Bravo G, Sasaki K, Haddad FG, Issa GC, Masarova L, Abbas HA, Andreeff M , Borthakur G, Mullin J, Tippett GD, Chien KS, Hammond D, Ishizawa J, Jain N, Reville PK, Swaminathan M, Yilmaz M, Daver N, Kadia TM, Ravandi F, Garcia-Manero G, Kantarjian HM, DiNardo CD

For instance, midazolam, an orally administered sedative drug, exhibits per-oral bioavailability of less than 10% in mice, rats, dogs, and monkeys, whereas its bioavailability exceeds 30% in humans 36 , highlighting pronounced species-dependent differences

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