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In fact, it can create DNA strand breaks caused by the formation of NO-dependent reactive species such as peroxynitrite, which directly attack the DNA and cause failure to correct single-strand breaks, leading to the formation of double-strand breaks, which are probably responsible for cell death

In these conditions, the gut lining is compromised, allowing endotoxins and other antigens to leak into the bloodstream and trigger an immune response

The figure shows robust expression of ZO-1 in epithelial enterocytes of small intestinal organoids (which is diminished under CARD9-inhibited conditions)

Instead, the majority of studies have been limited to monitoring a few markers of oxidative stress and other health indicators, usually assessed in blood samples