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Taken together, LA is a novel therapeutic in that it exhibits NSIT characteristics due to its nonsystemic, gut-restricted nature, and reaches the small intestine intact where it is hoped that it will have a therapeutic effect in human patients with celiac disease

(2023) published in The Lancet evaluated retatrutide dosing in subjects with type 2 diabetes

De Benedetto A, Rafaels NM, McGirt LY, Ivanov AI, Georas SN, Cheadle C, Berger AE, Zhang K, Vidyasagar S, Yoshida T, Boguniewicz M, Hata T, Schneider LC, Hanifin JM, Gallo RL, Novak N, Weidinger S, Beaty TH, Leung DY, Barnes KC, Beck LA