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Meanwhile, the ratio of GSR to GPX4 at the protein level was decreased in the A2ARi-treated group compared with the control group (Figure 3I), indicating that the GSSG accumulation upon A2ARi treatment is caused likely by an impaired capacity to recycle GSSG back to GSH

First, we systematically analyzed the ESCC cancer tissues and distant non-cancerous mucosa, as well as preoperative serum and urine samples from the same ESCC patients, to observe the common malignancy-related metabolic profiles in three samples

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Toward the rational control of transsulfuration