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Conversely, elevated membrane cholesterol reduces insulin-degrading enzyme (IDE) and neprilysin (NEP) activity, impairing A transport and clearance, thereby promoting SP formation (Wang et al., 2019)

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3032 Conversely, Akkermansia muciniphila , a bacterium capable of improving gut barrier function and metabolic health, is significantly reduced in MASLD patients, and its abundance is negatively correlated with the degree of hepatic steatosis

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