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Secondly, we did not have a placebo arm to compare with the treatment arm

This is to account for the fact that not all iron that is ingested will be digested and processed so by giving a higher dose, you are making up for the deficiency you may have

Intramuscular (IM) hydroxocobalamin injections bypass the intrinsic factor-mediated absorption mechanism, delivering the entire dose directly into circulation

In practice, estradiol cypionate injection is frequently integrated into comprehensive hormone-replacement programs that may co-administer micronized progesterone in women with an intact uterus to mitigate endometrial proliferation risks while aligning estradiol dosing with symptom relief and serum level targets