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These drugs work by inhibiting enzymes that promote inflammation (Kim 2010)

Vaginally applied estradiol or estriol is effective for genitourinary symptoms specifically, though estriol is not available as an FDA-approved product but is approved by regulatory agencies in other countries

Additionally, second-hand smoke also damages sperm motility through mitochondrial DNA damage and methylation, caused by excessive ROS ( Figure 2e ) (99, 100)