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Oncogene 36, 62826292 (2017)

In solvent -80C, 6 months , -20C, 1 month All Endogenous Metabolite Isoforms More Biological Activity 4 -11 is the deuterium labeled Hexacosanoic acid (HY-113301)

Specifically, the addition of cuprizone (bis-cyclohexanone oxalydihydrazone), to the diet process (66) produces a massive demyelination in different areas of the CNS and particularly in the corpus callosum (67-69)

This pathological state creates an imbalance where ROS and RNS production exceeds the neutralizing ability of intrinsic antioxidant systems, thereby establishing conditions of oxidative stress (Rahman and MacNee, 2000)