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however, external factors such as stress and aging cause it to be depleted in our bodies

However, both increased utilization of these vitamins for methylation and decreased intestinal absorption due to inflammation can alter the homocysteine cycle (225, 227, 228)

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Additionally, IPA functions as an allosteric inhibitor of TrpE by mimicking tryptophan, blocking the catalytic step of tryptophan synthesis mediated by TrpE, thus disrupting metabolic pathways in pathogens such as Mycobacterium tuberculosis and suppressing their proliferation (91)