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It can abstract hydrogen atoms from the deoxyribose sugar backbone, leading to strand breaks, or add to the double bonds of DNA bases, resulting in base modifications such as 8-hydroxydeoxyguanosine (8-OHdG) [28]

Consistent with the human genetic study, PGRN deficiency has been shown to exacerbate Gaucher disease-associated phenotypes of Gba1 D409V/D409V knockin mice [214]