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106 Glucokinase regulatory protein The glucokinase regulatory protein ( GCKR ) gene encodes glucokinase regulatory protein and is expressed mainly in the liver, pancreas, and colon

10.1101/cshperspect.a000158 49 JangJ

Wilhelm SM, Kale-Pradhan PB

[16] They include: [16] Neonatal hyperbilirubinemia, where the newborn's liver is not able to properly process the bilirubin causing jaundice Hepatocellular disease Viral infections (hepatitis A, B, and C) Chronic alcohol use Autoimmune disorders Genetic syndromes: Gilbert's syndrome a genetic disorder of bilirubin metabolism that can result in mild jaundice, found in about 5% of the population Rotor syndrome: non-itching jaundice, with rise of bilirubin in the patient's serum, mainly of the conjugated type DubinJohnson syndrome CriglerNajjar syndrome Pharmaceutical drugs (especially antipsychotic, some sex hormones, and a wide range of other drugs) Sulfonamides are contraindicated in infants less than 2 months old (exception when used with pyrimethamine in treating toxoplasmosis) as they increase unconjugated bilirubin leading to kernicterus