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The majority of the experiments were performed at least twice independently with multiple technical replicates performed for each independent experiment

For example, in the MPTP neurotoxicity mouse model discussed above, BHB induced neuroprotection by preventing the decline in mitochondrial respiration by acting on complex II (succinate-ubiquinone oxidoreductase) and restoring ATP production (20)

A large prospective cohort study (Ohsaki Cohort 2006) including 13,230 older adults (65) in Japan reported that frequent mushroom consumption (3 times/week) was significantly associated with a lower risk of incident dementia (HR = 0.81, 95% CI: 0.690.95) (21)