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In PCOS granulosa cells, elevated phosphorylation of the pro-apoptotic protein BAX, coupled with suppressed phosphorylation of the anti-apoptotic protein BCL-2, enhances mitochondrial pathway apoptosis, accelerating follicular atresia ( 3.6 Chronic low-grade inflammation Chronic low-grade inflammation have been identified as a central component in the pathogenesis of PCOS, rather than mere accompanying phenomena

In some embodiments, the antibodies encompassed by the present invention can be humanized antibodies

LTR Long Terminal Repeat GSH can safely raise cell levels beyond correcting GSH deficiencies

The residue was derivatized by addition of 40 l methoxyamine hydrochloride (15 mg/ml in pyridine) at 60 C for 2 h