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RSV was subsequently reported to increase phosphorylation of Akt and transcriptional activity of PPAR in the aorta of wild-type mice, thus supporting the hypothesis of SIRT1-PPAR interaction, and to strongly decrease LPC-induced mitochondrial ROS in the aortic endothelium of C57BL/6 mice ( Because of the pleiotropic actions of RSV, clinical trials are currently testing its therapeutic potential in a wide range of human diseases

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Moreover, a slight reduction in the inhibitory ability was observed when residue M44 was substituted with alanine