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As you get older, the systems that rely on NAD+ (like energy production, cognitive function, skin repair, immune health, and inflammation regulation) start to slow down, and declining NAD+ levels appear to be a key driver behind that slowdown

Elevated IGF-1 levels raise concerns about potential proliferative effects on existing malignancies, making growth hormone therapy problematic for individuals with cancer history or elevated cancer risk

Reviews typically cant control for confounders (diet changes, exercise, stimulant intake, sleep, stress, or other supplements), and negative experiences are often underreported