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Introduction Vitamin B12 (cobalamin) deficiency is prevalent in the elderly, with estimates indicating that approximately 20% of individuals aged 60 and over, and 23-35% of those aged 80 and above, are affected

It has been estimated that the complete methylation of just 0.1% of nucleosomes would exhaust the entire supply of intracellular SAM 65,66 , rendering the epigenome a critical consumer of SAM levels