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Traditionally, OS biomarkers used in male infertility include DNA damage, lipid peroxidation, and antioxidant enzyme activity (Figure 1)

Regarding triglyceride and VLDL cholesterol levels, it has been suggested that Zn affects the enzymes involved in lipid metabolism

however, continuous muscle injury triggers a chronic inflammatory response, which can aggravate the underlying lesions by degrading intact proteins, implying reduced performance and compromised health [52, 72, 73]

Here, we conducted an effectiveness trial to determine the effect of 12 months of low-dose niacin (a vitamin B3 derivative) enhancement in PD individuals