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For example, people who are experiencing loss of kidney function due to diabetes may find that high strength B12 supplementation can cause the loss of function to speed up (House et al., 2010), and high dose supplements of B12 may also increase the risk of colon cancer in older people

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Oxidative stress and antioxidant analysis To determine whether EGML and GCE supplementation provided protection against oxidative stress, the activity of the antioxidant enzymes catalase (CAT), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were measured in erythrocytes