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Data availability Nucleotide sequences of codon-optimized genes can be found in Supplementary Table 6

As shown, in-vivo and in-vitro studies have verified the impact of curcumin on the antioxidant defense system, lipid peroxidation levels, and ROS levels in hepatic cells of alcohol consumed subject (31, 33 and 76)

Available findings indicate that drugs targeting H3K27me3 can effectively inhibit tumor progression and overcome resistance to anticancer drugs, either alone or in combination with other therapies