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2 Relationships of L-Ergothioneine With Oxidative Stress-Related Diseases Oxidative stress and inflammation are key pathogenic factors in many diseases

Fe 3+ demonstrates a stronger binding affinity for -syn (131), potentially impacting -syn post-translational modifications or influencing Fe 2+ oxidation, thereby altering -syn fibril morphology and accelerating its aggregation (132)

In short, clinical data highlights the high prevalence of NPS and their worsening over the progression of AD (Liew, 2021)

130,131 In the brain, there are two primary pathways for Wnt signalling: (1) -catenin-dependent stabilized canonical signalling and (2) -catenin-independent noncanonical signalling