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PSO was also found to inhibit the activation of NF-B necessary for EMT

Multiple mechanisms are involved in the co-infection of cirrhosis

Smith FL, Lohmann AB, Dewey WL

Intracellular STEAP3, a metalloreductase, reduces Fe + to Fe + , which is then released into the labile iron pool (LIP) through the action of divalent metal transporter 1 (DMT1) (87)