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They are not interchangeable dose-for-dose

The genetic association observed appears to be equally applicable regardless of gender, though there was a significantly higher percentage of female participants in the case vs control group (Table 1)

The 12mg cohort achieved the highest mean body weight reduction at -24.2% exceeding all published results for semaglutide (approximately -16% in the STEP trials) and tirzepatide (approximately -22.5% in SURMOUNT-1) at their respective maximum doses