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Studies examining muscle protein synthesis, fiber hypertrophy in rodent models, and satellite cell biology have used IGF-1 LR3 as the standard research tool when sustained IGF1R activation is the experimental goal

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A prospective cohort study involving 266 elderly adults treated with epithalamin (the parent compound from which Epithalon was derived) over 2-3 years with subsequent 4-5 year follow-up demonstrated mortality reduction of 28% overall, with a 2-fold decrease in cardiovascular disease-specific mortality