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The latter is encoded by UGA and directed by the selenocysteine insertion sequence, SECIS element [28, 29], which serves as a platform for the recruitment of elongation factors of selenocysteine-tRNA [Ser]Sec (Sec-tRNA [Ser] Sec ) translation that decodes the UGA codon for the whole family of selenoproteins

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The current thought suggests that nitrate supplementation affords the greatest advantage in untrained individuals, but it is an effect that is diminished as the individual becomes more trained (Van De Walle and Vukovich, 2018)