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In general, payload release occurs in the TME or after cellular internalization within endosomal/lysosomal compartments, and in some systems may further proceed following endosomal escape, thereby determining the cytosolic availability of the active degrader [184,185,186]

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Due to the major changes in the classical constitutive proteins that have been generally used as loading controls [2123], here the equal loading was ensured by Ponceau protein assay after careful protein determinations

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